Ed Boas

F. Edward Boas

Associate professor, Interventional radiology
City of Hope Cancer Center
1500 East Duarte Rd.
Duarte, CA 91010

Interventional oncology bioengineering lab
ed.boas at gmail dot com

Research
Clinical
NIH biosketch
CV

Interventional oncology bioengineering lab

Shark tank pitch at RSNA: Local immunotherapy
Clinical trials:
Chemoembolization of lung metastases (bronchial or pulmonary artery)
Intra-arterial bumetanide for hepatocellular carcinoma (HCC)
DEB-TACE + nivolumab for HCC

Adjuvant medications for locoregional therapy. Aspirin appears to be hepatoprotective after embolization of hepatocellular carcinoma.

Hemangioma perfusion Liver perfusion imaging. Liver perfusion parameters estimated from triphasic CT can quantitate the increase in hepatic artery perfusion in hepatocellular carcinoma, and the decrease in portal perfusion with cirrhosis. They can also be used to classify liver lesions, predict response to radioembolization, and predict survival after TAE.

Cryoablation planning Cryoablation planning. We developed a planning tool that can accurately predict the size of the ice ball, and determine the optimal probe spacing and ablation time.

Reducing artifacts in CT scans. Patented method (MDT) for reducing metal artifacts in CT scans, which improves image quality in 86% of scans, and improves diagnosis in 14% of scans. This software has been successfully used on thousands of patients in more than 160 hospitals, including MGH, MD Anderson, and Stanford.

Claripacs - Annotate and share radiology studies on the web. Features include interactive multimedia radiology reports, screen share, and image analysis. 100,000 users have viewed 10 million images on Claripacs. Collaborators: Bao Do and Michael Muelly.

Optimal surveillance schedule
Transgastric pancreatic duct drain
Transcatheter aortic valve replacement planning tool
Virtual angiography
Optimal HCC surveillance schedule
Transgastric pancreatic duct drain

 

Selected recent publications Maxwell AWP, Mendoza HG, Sellitti MJ, Camacho JC, Deipolyi AR, Ziv E, Sofocleous CT, Yarmohammadi H, Maybody M, Humm JL, Schwartz J, Juluru K, Dunphy MP, Boas FE. (2022) "Optimizing 90Y particle density improves outcomes after radioembolization." Cardiovascular and Interventional Radiology. [ Author's version ]

Boas FE, Kemeny NE, Sofocleous CT, Yeh R, Thompson VR, Hsu M, Moskowitz CS, Ziv E, Yarmohammadi H, Bendet A, Solomon SB. (2021) "Bronchial or Pulmonary Artery Chemoembolization for Unresectable and Unablatable Lung Metastases: A Phase I Clinical Trial." Radiology. 301(2): 474-84.

Nurili F, Monette S, Michel AO, Bendet A, Basturk O, Askan G, Cheleuitte-Nieves C, Yarmohammadi H, Maxwell AWP, Ziv E, Schachtschneider KM, Gaba RC, Schook LB, Solomon SB, Boas FE. (2021) "Transarterial embolization of liver cancer in a transgenic pig model." Journal of Vascular and Interventional Radiology. 32(4): 510-7.

Boas FE, Nurili F, Bendet A, Cheleuitte-Nieves C, Basturk O, Askan G, Michel AO, Monette S, Ziv E, Sofocleous CT, Maxwell AWP, Schook LB, Solomon SB, Kelsen DP, Scherz A, Yarmohammadi H. (2020) "Induction and characterization of pancreatic cancer in a transgenic pig model." PLOS ONE. 15(9): e0239391.

Boas FE, Brown KT, Ziv E, Yarmohammadi H, Sofocleous CT, Erinjeri JP, Harding JJ, Solomon SB. (2019) "Aspirin is associated with improved liver function after embolization of hepatocellular carcinoma." AJR. 213:689-95. More info »

Zener R, Yoon H, Ziv E, Covey A, Brown KT, Sofocleous CT, Thornton RH, Boas FE. (2019) "Outcomes after transarterial embolization of neuroendocrine tumor liver metastases using spherical particles of different sizes." Cardiovascular and Interventional Radiology. 42: 569-76.

Maybody M, Muallem N, Brown KT, Moskowitz CS, Hsu M, Zenobi CL, Jihad M, Getrajdman GI, Sofocleous CT, Erinjeri JP, Covey AM, Brody LA, Yarmohammadi H, Deipolyi AR, Bryce Y, Alago W, Siegelbaum RH, Durack JC, Gonzalez-Aguirre AJ, Ziv E, Boas FE, Solomon SB. (2019) "Autologous blood patch injection versus hydrogel plug in CT-guided lung biopsy: A prospective randomized trial." Radiology. 290: 547-54.

Borgheresi A, Gonzalez-Aguirre A, Brown KT, Getrajdman GI, Erinjeri JP, Covey A, Yarmohammadi H, Ziv E, Sofocleous CT, Boas FE. (2018) "Does enhancement or perfusion on pre-procedure CT predict outcomes after embolization of hepatocellular carcinoma?" Academic Radiology. 25(12): 1588-94. More info »

Sofocleous CT, Boas FE. (2018) "Radiation segmentectomy for hepatocellular carcinoma: Ready for prime time?" Radiology. 287: 1059-60.

Boas FE, Bodei L, Sofocleous CT. (2017) "Radioembolization of colorectal liver metastases: Indications, technique, and outcomes." J Nucl Med. 58: 104S-111S.

Boas FE, Ziv E, Yarmohammadi H, Brown KT, Erinjeri JP, Sofocleous CT, Harding JJ, Solomon SB. (2017) "Adjuvant medications that improve survival after locoregional therapy." Journal of Vascular and Interventional Radiology. 28(7): 971-977. More info »

Boas FE, Srimathveeravalli G, Kaye EA, Durack JC, Erinjeri JP, Ziv E, Maybody M, Yarmohammadi H, Solomon SB. (2017) "Development of a searchable database of cryoablation simulations, for use in treatment planning." Cardiovascular and Interventional Radiology. 40(5): 761-8. More info »

Boas FE, Brody LA, Erinjeri JP, Yarmohammadi H, Shady W, Kishore S, Sofocleous CT. (2016) "Quantitative enhancement measurements on preprocedure triphasic CT can predict response to radioembolization of colorectal liver metastases." AJR. 207: 671-5. More info »

Ziv E, Erinjeri JP, Yarmohammadi H, Boas FE, Petre EB, Gao S, Shady W, Sofocleous CT, Jones DR, Rudin CM, Solomon SB. (2016) "Lung adenocarcinoma: Predictive value of KRAS mutation status in assessing local recurrence in patients undergoing image-guided ablation." Radiology. 282(1): 251-8.

Boas FE, Kadivar F, Kelly PD, Drebin JA, Vollmer CM, Shlansky-Goldberg RD. (2015) "Targeted transgastric drainage of isolated pancreatic duct segments to cure persistent pancreaticocutaneous fistulas from pancreatitis." J Vasc Interv Radiol. 26(2): 247-51. More info »

Boas FE, Do B, Louie JD, Kothary N, Hwang GL, Kuo WT, Hovsepian DM, Kantrowitz M, Sze DY. (2015) "Optimal imaging surveillance schedules after liver-directed therapy for hepatocellular carcinoma." J Vasc Interv Radiol. 26(1): 69-73. More info »

Boas FE, Kamaya A, Do B, Desser TS, Beaulieu CF, Vasanawala SS, Hwang GL, Sze DY. (2015) "Classification of hypervascular liver lesions based on hepatic artery and portal vein blood supply coefficients calculated from triphasic CT scans." Journal of Digital Imaging. 28: 213-23. More info »

Boas FE. (2012) "Iterative reduction of artifacts in computed tomography images using forward projection and an edge-preserving blur filter." U.S. Patent 8233586.

Boas FE and Fleischmann D. (2012) "Computed tomography artifacts: Causes and reduction techniques." Imaging in Medicine. 4(2): 229-40. More info »

Boas FE and Fleischmann D. (2011) "Evaluation of two iterative techniques for reducing metal artifacts in computed tomography." Radiology. 259(3): 894-902. More info »

Fleischmann D and Boas FE. (2011) "Computed tomography: Old ideas and new technology." European Radiology. 21: 510-17.

More publications
Patent applications Boas FE, Erinjeri J. (2019) "Intra-arterial injection of vaccine adjuvants into tumors for treatment of metastatic cancer." US Prov. Appl. No. 62/817,116. [ Licensing information ]

Boas FE. (2018) "Improved intra-arterial tumor targeting using an omniphobic oil." US Prov. Appl. No. 62/754,139. [ Licensing information ]

Boas FE. (2012) "Iterative reduction of artifacts in computed tomography images using forward projection and an edge-preserving blur filter." U.S. Patent 8233586. [ Licensing information ]

Selected book chapters Boas FE. (2022) "Embolization for lung tumors." In Fong Y, Covey A, Ahmed M, Kessler J, Iannitti D, and Dupuy D (Eds.), Interventional Oncology: Multidisciplinary Approach to Image-Guided Cancer Therapy, 2nd ed. Springer Nature. In press.

Boas FE and Solomon SB. (2022) "Postoperative complications requiring intervention: Diagnosis and management." In WR Jarnagin (Ed.), Surgery of the Liver, Biliary Tract, and Pancreas, 7th ed. New York, NY: Elsevier. In press.

Boas FE and Sofocleous CT. (2020) "Embolotherapy for the Management of Liver Malignancies Other Than Hepatocellular Carcinoma." In Mauro MA, Murphy KP, Thomson KR, Venbrux AC, and Morgan RA (Eds.), Image-Guided Interventions, 3rd edition, Expert Radiology Series.

Solomon SB, Griffin JF, Weiss MJ, Boas FE. (2016). "Postoperative complications requiring intervention: Diagnosis and management." In WR Jarnagin (Ed.), Blumgart's Surgery of the Liver, Biliary Tract, and Pancreas, 6th ed. New York, NY: Elsevier.

Boas FE, Shlansky-Goldberg RD. (2015). "Role of interventional radiology in managing bile duct injuries." In Dixon E, Vollmer CM, May GR (Eds.), Management of Benign Biliary Stenosis and Injury: A Comprehensive Guide. New York, NY: Springer.

Press Aspirin improves liver function after embolization of hepatocellular carcinoma. EurekAlert, AAAS, 2019-07-31.

Memorial Sloan Kettering develops new tool for planning cryoablation procedures. Medgadget, 2017-01-13.

A New Planning Tool for Cryoablation: An Interview With Franz Edward Boas, MD. Interventional Oncology 360°, 2016-05-17. [ Video | Transcript ]

Selected talks / abstracts 2022-06-14: SIR 2022. Youssef EW, Ghosn M, El Hawari M, Fine GC, Maybody M, Yarmohammadi H, Brown KT, Boas FE. "Portal vein stent placement for malignant portal vein occlusion."

2022-06-12: SIR 2022. Maxwell AWP, Mendoza HG, Sellitti MJ, Camacho JC, Deipolyi AR, Ziv E, Sofocleous CT, Yarmohammadi H, Maybody M, Humm JL, Schwartz J, Juluru K, Dunphy MP, Boas FE. "Optimizing 90Y particle density improves outcomes after radioembolization."

2022-06-12: SIR 2022. Boas FE. "Transarterial Chemoembolization of Lung Metastases."

2022-03-26: SIO 2022. Boas FE. "Transarterial Chemoembolization of Lung Metastases."

2021-06-04: ASCO 2021. Boas FE, Kemeny NE, Sofocleous CT, Yeh R, Thompson VR, Hsu M, Moskowitz CS, Ziv E, Yarmohammadi H, Bendet A, Solomon SB. "Phase I Study of Transarterial Chemoembolization of Lung Metastases."

2021-03-26: SIR 2021. Yarmohammadi H, Elsakka AS, Nurili F, Maxwell AWP, Ridouani F, Ziv E, O'Reilly EM, Cheleuitte-Nieves C, Schook LB, Solomon SB, Boas FE. "Treatment of pancreatic cancer by intra-arterial injection of an emulsion of Lipiodol and bumetanide (an anti-glycolytic drug) in a transgenic mutated pig model (Oncopig)."

2021-02-28: APSCVIR 2021. Boas FE. "New intra-arterial therapies for extrahepatic disease."

2020-11-30: RSNA 2020. Boas FE. "Special Interest Session: The Academy Imaging Shark Tank."

2020-03-29: SIR 2020, Seattle. Boas FE. "New intra-arterial therapies for pancreatic and lung cancer."

2020-03-31: SIR 2020, Seattle. Nurili F, Bendet A, Monette S, Michel A, Basturk O, Askan G, Cheleuitte-Nieves C, Yarmohammadi H, Schachtschneider KM, Gaba RC, Schook LB, Solomon SB, Boas FE. "Transarterial embolization of liver cancer in a transgenic pig model." [ Abstract | Video ]

2020-03-31: SIR 2020, Seattle. Boas FE, Nurili F, Bendet A, Cheleuitte-Nieves C, Basturk O, Askan G, Monette S, Michel A, Schook LB, Solomon SB, Kelsen DP, Scherz A, Yarmohammadi H. "Development of a transgenic pig model of pancreatic cancer." [ Abstract | Video ]

More talks
Funding PI, "Phase II trial of lung chemoembolization." Guerbet (investigator initiated). 2022-2024.

Co-PI (with Lawrence Schook, Ron Gaba, Stephen Solomon, Karen Brown), "Genetically Inducible Porcine Model of Primary and Metastatic HCC in Comorbidity Host Environments for Interventional Radiology-Guided Detection and Treatment." Department of Defense, Congressionally Directed Medical Research Programs. 08/01/2016 - 07/31/2020.

PI, "Phase I study of transarterial chemoembolization of lung metastases." Society of Interventional Oncology, Transarterial lipiodol chemoembolization research grant. 2019 - 2020.

PI, "Phase I study of transarterial chemoembolization of lung metastases." Brockman Medical Research Foundation. 2019 - 2021.

Aim co-leader, "Targeting pancreatic cancer." Thompson family foundation. 2017 - 2022.


CT metal artifact reduction | Claripacs (web PACS) | Other projects |
City of Hope IR | My Google Scholar page
Last updated: 2022-06-13